발육중인 흰쥐 치배 및 그 주위조직에서의 Bone Sialoprotein분포에 관한 면역조직화학적 연구
Immunohistochemical Localization of Bone Sialoprotein in Developing rat Dental Tissues
곽경숙, 정희숙,
소속 상세정보
곽경숙 ( ) - 경희대학교 식품공학과
정희숙 ( ) - 경희대학교
KMID : 0355819930170010051
Abstract
Bone sialoprotein (BSP) is a highly sulphated and glycosylated phosphoprotein that is a major constituent oif bone and other mineralized connective tissues. Although BSP can mediate cell attachment through an RGD sequence and binds selectively to
hydroxyapatite, its precise function in mineralized tissues is unknown. To provide insights into its possible function, affinity-purified polyclonal antibodies directed against rat BSP were used to demonstrate the histological distribution of
this
protein in developing dental tissues from 14-day-old rats.
@ES The results were as follows ;
@EN 1. Immunoreactivity for BSP was restricted to the cells and matrix of the mineralized tissues of dentin, alveolar bone and acellular cementum.
2. Immunoreactivity for BSP was evident in osteobiastic cells and osteocytes and in the bone matrix ; the formed bone was stained more strongly than the older bone.
3. In dentin, BSP was localized to the odontoblasts and peritubular dentin.
4. BSP was present within the matrix of acellular cementum : this adhesion protein seemed to have an activity of attachment to the cementum.
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